Unravelling the association between metformin and pan-cancers: Mendelian randomization combined with NHANES database analysis

Our findings indicate a significant protective effect of metformin against prostate and ovarian cancer based on MR analysis. NHANES data further support a general protective effect of metformin against cancer. These findings warrant consideration of metformin in the context of cancer prevention and potential therapeutic strategies for prostate and ovarian cancer, though further research is needed to fully elucidate its mechanisms of action and establish its role in anti-cancer therapy.