Brief hypothermic oxygenated perfusion provides cardioprotection in a pig model of donation after circulatory death
A brief period of hypothermic oxygenated perfusion, applied as a reperfusion therapy between graft procurement and normothermic machine perfusion, provides cardioprotection in a porcine model of donation after circulatory death. Hypothermic oxygenated perfusion is a promising, easily applicable, cardioprotective reperfusion strategy; this study provides key evidence to support clinical translation.
Authors
- Alexia Clavier (ORCID: https://orcid.org/0009-0004-3682-8667)
- Selianne Graf (ORCID: https://orcid.org/0009-0000-8708-4996)
- Maris Bartkevics (ORCID: https://orcid.org/0000-0003-1303-2418)
- Peter Vermathen (ORCID: https://orcid.org/0000-0001-8649-1098)
- Alexander Kadner (ORCID: https://orcid.org/0000-0003-3024-6514)
- Manuel Egle (ORCID: https://orcid.org/0009-0000-6368-7397)
- Maria Arnold (ORCID: https://orcid.org/0000-0003-4146-404X)
- Sarah Longnus (ORCID: https://orcid.org/0000-0001-8489-917X)
- Anja Helmer (ORCID: https://orcid.org/0009-0001-0575-4616)
- Matthias Siepe (ORCID: https://orcid.org/0000-0003-3305-9343)
- Fabio Zulauf (ORCID: https://orcid.org/0000-0002-8309-0309)
- Adrian Segiser (ORCID: https://orcid.org/0009-0006-5796-1429)
- Rahel Ottersberg (ORCID: https://orcid.org/0009-0009-8457-1938)
- Georgia Beer
- Deborah Lagger
- Daja Krummenacher (ORCID: https://orcid.org/0009-0004-2735-8827)
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- University Hospital of Bern (CH)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1093/ejcts/ezaf061
- Citations
- 2
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.01