Risk Factors for Antibiotic Exposure Post Fecal Microbiota Transplantation for Recurrent <i>Clostridioides difficile</i> Infection, A Prospective Multicenter Observational Study
Non-CDI antibiotic exposure significantly increases the risk of CDI recurrence post-FMT. Risk factors for non-CDI antibiotic administration within 2 months of FMT include immunocompromised status, multiple prior non-CDI antibiotics, and prior hospitalization for CDI. These individuals may benefit from additional or modified recurrent CDI prevention strategies.
Authors
- Byron P. Vaughn (ORCID: https://orcid.org/0000-0001-5081-3761)
- William Hirsch (ORCID: https://orcid.org/0000-0003-2849-659X)
- Colleen R. Kelly (ORCID: https://orcid.org/0000-0003-2996-747X)
- Jessica Ravikoff Allegretti (ORCID: https://orcid.org/0000-0003-3585-2425)
- Alexander Khoruts (ORCID: https://orcid.org/0000-0002-3205-3188)
- Monika Fischer (ORCID: https://orcid.org/0000-0001-7162-6172)
Institutions
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- Biotechnology Institute (US)
- Harvard University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/ofid/ofaf130
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00