Are all mismatch repair deficient endometrial cancers created equal? A large, retrospective, tertiary center experience
MLH1-hypermethylated MMRd ECs display more aggressive clinicopathologic features compared to the other MMRd subgroups. However, although a suggestive trend toward poorer EFS was observed in the hypermethylated subset, particularly in the advanced setting, no significant differences in prognosis were detected among the MMRd subtypes.
Authors
- Laura Remondini
- Giovanni Esposito
- Simona Duranti (ORCID: https://orcid.org/0000-0002-1924-238X)
- Maria Grazia Pomponi (ORCID: https://orcid.org/0000-0002-0417-9939)
- Alessia Piermattei (ORCID: https://orcid.org/0000-0001-7164-4952)
- Francesco Fanfani (ORCID: https://orcid.org/0000-0003-1991-7284)
- Giovanni Scambia (ORCID: https://orcid.org/0000-0002-9503-9041)
- Emanuela Lucci‐Cordisco (ORCID: https://orcid.org/0000-0002-6279-7604)
- Angela Santoro (ORCID: https://orcid.org/0000-0002-6964-5152)
- Ilaria Capasso (ORCID: https://orcid.org/0000-0001-5987-6654)
- Emanuele Perrone (ORCID: https://orcid.org/0000-0002-0938-2493)
- Michele Valente
- Camilla Nero (ORCID: https://orcid.org/0000-0002-4442-4046)
- Diana Giannarelli (ORCID: https://orcid.org/0000-0002-6085-1195)
- Giancarlo Parisi
- Martina Corrado
- Maria Consiglia Giuliano
Institutions
- Agostino Gemelli University Polyclinic (IT)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.ejca.2025.115344
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.36