Inhalation of 5% CO2 and activation of ASIC1a: a potential therapeutic approach for Dravet syndrome
After CO<sub>2</sub> inhalation, the expression of the ASIC1a protein in the hippocampus increased, the duration of hyperthermia-induced seizures was reduced in Scn1a<sup>+/-</sup> mice, and the damage to hippocampal neurons was alleviated.
Authors
- Jie Wang (ORCID: https://orcid.org/0000-0001-8850-4251)
- Lu Qian (ORCID: https://orcid.org/0000-0001-6742-907X)
- Haiqing Zhao
- Li‐Ping Zou (ORCID: https://orcid.org/0000-0001-7233-9378)
- Yangyang Wang (ORCID: https://orcid.org/0000-0002-2095-5002)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-7027-3915)
- Qiuhong Wang (ORCID: https://orcid.org/0000-0002-3694-9037)
Institutions
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- First Hospital of Qinhuangdao (CN)
Publication Details
- Journal
- Acta Epileptologica
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s42494-025-00204-8
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47