Elastic scattering spectroscopy for intraoperative oral cancer mucosal margin guidance: Initial results from a 104 patient cohort
The ESS device demonstrated high sensitivity and appropriate specificity when differentiating benign from malignant tissue. Discriminant ability increased when samples were pooled within patients, informing future protocols for evaluating intraoperative ESS measures. These data are very promising and support the contention that ESS could be a valuable adjunct tool that facilitates comprehensive and efficient assessment of surgical margins.
Authors
- R. Pistey
- Ziyue Lu (ORCID: https://orcid.org/0009-0000-5913-6189)
- Eladio Rodriguez‐Diaz (ORCID: https://orcid.org/0000-0001-7750-9110)
- Jane Tracy (ORCID: https://orcid.org/0000-0002-4070-8615)
- Marcus Couey (ORCID: https://orcid.org/0000-0002-9464-2682)
- Irving J. Bigio (ORCID: https://orcid.org/0000-0003-4168-1466)
- Gintas P. Krisciunas (ORCID: https://orcid.org/0000-0001-7083-4279)
- David R. Lucas (ORCID: https://orcid.org/0000-0001-8751-0238)
- Guoguang Zhao (ORCID: https://orcid.org/0000-0002-7569-5252)
- Miriam O’Leary (ORCID: https://orcid.org/0000-0002-6357-2685)
- Meena Kishore Sakharkar (ORCID: https://orcid.org/0000-0002-9289-3314)
- Kelly Sayre (ORCID: https://orcid.org/0000-0002-3051-6222)
- June Hanks (ORCID: https://orcid.org/0009-0009-5353-363X)
- Hugh Edwards (ORCID: https://orcid.org/0000-0003-0305-1121)
- Ousama M. A’Amar
- Gregory A. Grillone (ORCID: https://orcid.org/0000-0002-7243-7522)
- John Gooey
- Leanne Berry
- G Spokas
Institutions
- Boston University (US)
- Tufts University (US)
- Boston Medical Center (US)
- Tufts Medical Center (US)
- VA Boston Healthcare System (US)
- Boston VA Research Institute (US)
Publication Details
- Journal
- American Journal of Otolaryngology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.amjoto.2025.104605
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Dental and Craniofacial Research
- National Center for Advancing Translational Sciences