Impact of Different Mediastinal Staging Modalities on Target Volume Delineation in Locally Advanced Non-Small Cell Lung Cancer: A Secondary Analysis of the Multicenter Randomized PET-Plan Trial
In this unplanned secondary analysis of the PET-Plan trial, the additional use of invasive staging resulted in relevant changes to the target volume in a tenth of patients. Invasive staging did not, however, have an effect on outcome in this trial, with a low rate of isolated out-of-field recurrences (6 in arm A vs 3 in arm B). Radiation treatment planning can thus be based on invasive staging in addition to noninvasive PET in patients undergoing definitive chemoradiation therapy for locally advanced non-small cell lung cancer. Prospective randomized data are required to confirm these findings.
Authors
- Jörg Sahlmann (ORCID: https://orcid.org/0000-0003-3023-3318)
- Daiana Stolz (ORCID: https://orcid.org/0000-0003-0099-882X)
- Matthias Miederer (ORCID: https://orcid.org/0000-0001-5075-5995)
- Harald Binder (ORCID: https://orcid.org/0000-0002-5666-8662)
- Eleni Gkika (ORCID: https://orcid.org/0000-0001-5455-252X)
- Cas Stefaan Dejonckheere (ORCID: https://orcid.org/0000-0003-4527-4024)
- Alexander Brose (ORCID: https://orcid.org/0000-0001-8033-6855)
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- J. König (ORCID: https://orcid.org/0000-0003-4683-0360)
- Andreas Rimner (ORCID: https://orcid.org/0000-0002-1214-3856)
- Markus Hecht (ORCID: https://orcid.org/0000-0003-2082-216X)
- Cornelius F. Waller (ORCID: https://orcid.org/0000-0002-5777-0212)
- Sonja Adebahr
- Tanja Schimek‐Jasch (ORCID: https://orcid.org/0000-0003-2027-9320)
- Severin Schmid (ORCID: https://orcid.org/0000-0001-8077-082X)
- Ursula Nestle
- Simeon Ari Barth
Institutions
- University of Freiburg (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Universitätsklinikum Gießen und Marburg (DE)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Kliniken Maria Hilf (DE)
- National Center for Tumor Diseases (DE)
- University Hospital Carl Gustav Carus (DE)
- Institute for Medical Informatics and Biostatistics (CH)
- Saarland University (DE)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.02.041
- Citations
- 1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Deutsche Krebshilfe