Integration proteomics analysis to identify AMPK as key target pathways of TCM formula for high fat diet induced obesity in mice
LAH reduces the expression of FAS and SREBP1 proteins <i>via</i> the AMPK pathway, while enhancing the activity of antioxidant enzymes. These effects promote weight loss and improve hepatic lipid metabolism, supporting its potential as a therapeutic agent for obesity and related metabolic disorders. This provides a theoretical foundation for using LAH in weight management.
Authors
- Ching‐Chiung Wang (ORCID: https://orcid.org/0000-0002-5259-3931)
- De-Shan Ning
- Chia‐Jung Lee (ORCID: https://orcid.org/0000-0002-9416-5468)
- Yu‐Ju Chen (ORCID: https://orcid.org/0000-0002-3178-6697)
- Ming-Chung Lee (ORCID: https://orcid.org/0000-0001-9691-3872)
- Wan‐Chun Chiu (ORCID: https://orcid.org/0000-0003-4638-5412)
- J.M. Vega
- Chiu‐Li Yeh (ORCID: https://orcid.org/0000-0001-8245-4601)
- Kun-Teng Wang
- Zhao Hongwei
Institutions
- Taipei Medical University Hospital (TW)
- Infinitus (China) (CN)
- Taipei Medical University (TW)
- Atotech (United States) (US)
Publication Details
- Journal
- Journal of Traditional and Complementary Medicine
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1016/j.jtcme.2025.02.010
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00