PGAM5 Modulates Macrophage Polarization, Aggravating Inflammation in COPD via the NF-κB Pathway
PGAM5 can cause an increase in p-ASK1<sup>T838</sup>, trigger the NF-κB pathway activation, and stimulate the M1 macrophage polarization and production of proinflammatory factors. This finding has significant implications for preventing and treating COPD.
Authors
- Lipeng Zhang (ORCID: https://orcid.org/0000-0003-0898-2400)
- Yu Zheng (ORCID: https://orcid.org/0000-0001-8424-6611)
- Qiaoyu Li (ORCID: https://orcid.org/0000-0002-2442-4866)
- Jia Li (ORCID: https://orcid.org/0000-0002-1353-7347)
- Yujie Wang (ORCID: https://orcid.org/0000-0001-9292-2229)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7199-4784)
- F. Ling
- Qiong Feng
- Shaomao Zheng
- Qiuli Nie
- Chengji Jin
Institutions
- Hainan Medical University (CN)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/copd.s492627
- Citations
- 2
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.59