miR-183-5p-enriched extracellular vesicles promote the crosstalk between hepatocellular carcinoma cell and endothelial cell via SIK1/PI3K/AKT and CCL20/CCR6 signaling pathways
The findings indicated that miR-183-5p delivered by EVs from HCC cells is crucial in mediating the communication between HUVECs and HCC cells by modulating the SIK1/PI3K/AKT and CCL20/CCR6 signaling pathways, and EVs-miR-183-5p might be a potential therapeutic target for HCC patients.
Authors
- Ye Han (ORCID: https://orcid.org/0000-0002-2180-2817)
- Weili Xue (ORCID: https://orcid.org/0000-0002-1885-3920)
- Xian‐Li Zhou (ORCID: https://orcid.org/0000-0002-1690-0578)
- Xiaolei Wang (ORCID: https://orcid.org/0000-0002-6950-4309)
- Wei Gong (ORCID: https://orcid.org/0000-0002-9949-6207)
- Xu Yi (ORCID: https://orcid.org/0000-0001-7802-6743)
- Xin‐Hui Xing (ORCID: https://orcid.org/0000-0001-6419-4770)
- Hang Zhou
Institutions
- Harbin Medical University (CN)
- Chinese University of Hong Kong (HK)
- Second Affiliated Hospital of Harbin Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fonc.2025.1532239
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42