Associations of ANGPT2 expression and its variants (rs1868554 and rs7825407) with multiple myeloma risk and outcome
Our results showed that <i>ANGPT2</i> expression at the mRNA level correlates with CRP, a negative prognostic factor in MM. The ANGPT2 protein is a proangiogenic factor, and its concentration is significantly greater in MM patients than in healthy individuals, which was also confirmed in our research. Therefore, this protein with VEGF and HB-EGF, should be considered in the future as a markers of angiogenesis in MM.
Authors
- Katarzyna Sidor (ORCID: https://orcid.org/0000-0003-2590-3970)
- Szymon Zmorzyński (ORCID: https://orcid.org/0000-0002-2039-2908)
- Wojciech Styk (ORCID: https://orcid.org/0000-0003-0186-3118)
- Marek Hus (ORCID: https://orcid.org/0000-0002-9036-6625)
- Sylwia Popek-Marciniec (ORCID: https://orcid.org/0000-0003-0783-6153)
- Grażyna Świderska-Kołacz (ORCID: https://orcid.org/0000-0002-4839-2248)
- Aneta Szudy‐Szczyrek (ORCID: https://orcid.org/0000-0003-2352-394X)
- Joanna Czerwik-Marcinkowska (ORCID: https://orcid.org/0000-0003-2019-7819)
- Sylwia Chocholska (ORCID: https://orcid.org/0000-0002-5001-9258)
Institutions
- Medical University of Lublin (PL)
- Jan Kochanowski University (PL)
- State Higher School of Vocational Education in Zamość (PL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fonc.2025.1468373
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00