Nuclear receptor 4A1 is critical for neutrophil-dependent pulmonary immunity to Klebsiella pneumoniae infection
Neutrophil <i>Nr4a1</i> expression is critical for defense against <i>K. pneumoniae</i> infection by regulating the neutrophil transcriptome. These findings suggest targeting <i>Nr4a1</i> signaling pathways in neutrophils may be useful for bacterial pneumonia treatment.
Authors
- Matthew Henkel
- Taylor Eddens (ORCID: https://orcid.org/0000-0003-2969-3624)
- Norie Sugitani (ORCID: https://orcid.org/0000-0002-5582-8855)
- Jessica Partyka
- Brian T. Campfield (ORCID: https://orcid.org/0000-0002-5380-9837)
- Craig A. Byersdorfer (ORCID: https://orcid.org/0000-0002-0030-3699)
- Felicia Kemp
- Alexander Applegate
Institutions
- University of Minnesota (US)
- University of Pittsburgh (US)
- Children's Hospital of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1558252
- Citations
- 4
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.64