Microglia-derived CXCL2 induced neuronal ferroptosis via CXCR2/Jun axis in sepsis-associated encephalopathy
In conclusion, microglia-derived CXCL2 could induce the occurrence of neuronal ferroptosis by targeting Jun. Thus, regulating the expression and secretion of CXCL2 will probably be a crucially novel strategy for the treatment of SAE.
Authors
- Yu-Shen Yang (ORCID: https://orcid.org/0000-0003-0310-3999)
- Yuming Fang (ORCID: https://orcid.org/0000-0002-6946-3586)
- Zhendong Sun (ORCID: https://orcid.org/0000-0003-2134-6652)
- He-Fan He (ORCID: https://orcid.org/0000-0001-9622-4110)
- Meng-Qin Pei
- Jin-Wei Liang
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fimmu.2024.1512300
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21