Multi-omics analysis reveals that low cathepsin S expression aggravates sepsis progression and worse prognosis via inducing monocyte polarization
Monocyte marker <i>CTSS</i> represent a promising target for the diagnosis and prognosis evaluation of sepsis and plays a critical role in monocytes activation, tissue inflammatory response and macrophages infiltration. Thus, <i>CTSS</i> agonist probably serves as new drug for clinical protection against sepsis.
Authors
- Zhendong Sun (ORCID: https://orcid.org/0000-0003-2134-6652)
- Huirong Hu (ORCID: https://orcid.org/0000-0002-4447-8722)
- Yan Li (ORCID: https://orcid.org/0000-0003-2233-7061)
- Xiaoting Luo
- Lihong Zhang (ORCID: https://orcid.org/0000-0003-2100-795X)
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fcimb.2025.1531125
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39