ENDOMETRIAL ENIGMAS: A HISTOPATHOLOGICAL EXPLORATION OF ABNORMAL UTERINE BLEEDING IN WOMEN PRESENTING IN TERTIARY CARE HOSPITAL

Background: Abnormal uterine bleeding (AUB) affects 10-20% of reproductive-age women, strongly impacting quality of life and reproductive health. Endometrial biopsy is crucial for diagnosing underlying pathologies. Various studies report differing histopathological findings with limited data on specific populations, highlighting the need for comprehensive data. Objective/s: To determine the histopathological pattern of endometrial biopsies performed in women presenting with abnormal uterine bleeding & to analyze the frequency of various histopathology patterns identified. Study settings: Cross-sectional study conducted at Department of Obstetrics & Gynecology, Central Park Teaching Hospital, Lahore from 15-06-2023 to 14-12-2023 Methodology: One hundred and fifty females with abnormal uterine bleeding were enrolled who underwent biopsy by dilation and curettage. Findings of histopathological reports were recorded. Data was analyzed in SPSS ver. 26. Results: The current study showed that participants' mean age was 46.23 ± 17.18 years. The most common complaints of abnormal uterine bleeding were post-menopausal bleeding (33.3%), heavy irregular menstrual bleeding (33.3%), and cyclical heavy bleeding (18.7%). The most common pathology was functional endometrium (50%), followed by endometrial atrophy (14.0%), benign lesions (11.3%), malignant lesions (7.3%), inflammatory endometrium (1.3%), and few others were observed in 16% cases. Conclusion: The most common pathology in local population observed on histopathology was functional endometrium, while malignant lesions were less frequent.