In-Vivo Screening of Acid-Neutralising Capacity of Methanolic Extract of Achyranthes aspera

Background and Aim: The possible antiulcer qualities of the Amaranthaceae family have drawn interest. Alternative treatments for peptic ulcers, a common gastrointestinal ailment, must be investigated; Amaranthaceae species may provide encouraging leads in this respect. As a result, we have chosen Achyranthes aspera from the Amaranthaceae family to assess its antiulcer and antioxidant qualities. Methodology: Using petroleum ether, chloroform, methanol, and water, the plant components were extracted by the successive Soxhlet extraction procedure. The stable "1,1-diphenyl-2-picrylhydrazyl" (DPPH) free radical action and hydrogen peroxide process were taken into account while evaluating the antioxidant activity of the plant extracts and the conventional medications. The methanolic extract of Achyranthes aspera (MEAA) was tested for its antiulcer properties using pyloric ligation and ulcers caused by non-steroidal anti-inflammatory drugs. Result: Triterpenoids, flavonoids, alkaloids, tannins, glycosides, and proteins are all detected by phytochemical analysis of methanolic extracts. According to the findings of the antioxidant investigation, the MEAA has the highest potential for antioxidant activity among the four extracts. The extract-treated classes and the standard class showed a substantial (p<0.05) decrease in stomach volume, total, and free acidity as compared to the control. With 500 mg/ml PL and NSAID, the MEAA showed significant (p<0.05) percent inhibition, i.e., 59.42 and 69.59 percent, respectively. Conclusion: The results of this study showed that Achyranthes aspera's methanolic extract had strong antiulcer and antioxidant properties.