Exploring The Antidiabetic and Nephroprotective Potential of Litsea Glutinosa: A Natural Remedy for Metabolic and Cellular Stress

This study evaluates the pharmacological potential of Litsea glutinosa (L.) leaves extract, a natural plant-derived extract, with a focus on its antidiabetic and nephroprotective activities. Phytochemical screening revealed the extracts as a rich source of bioactive compounds, including flavonoids, tannins, phenols, and terpenoids, which are known for their therapeutic benefits. The glucose utilization assay in L6 myoblasts demonstrated extracts’s significant enhancement of glucose uptake in a dose-dependent manner, highlighting its antidiabetic potential. In the DPP-4 inhibition assay, the potential extract (LG-M) exhibited moderate inhibitory activity, further supporting its role in glucose regulation. Additionally, nephroprotective activity was assessed in cisplatin-induced toxicity in HEK-293 cells. LG-M showed superior cell viability preservation compared to the standard drug Paclitaxel, indicating its protective effect against nephrotoxicity. The total phenolic content analysis confirmed LG-M’s robust antioxidant properties, which may contribute to its observed pharmacological effects. Statistical analysis validated the significance of these findings. This comprehensive evaluation underscores LG-M’s potential as a natural therapeutic agent for managing diabetes and mitigating nephrotoxicity. Further studies on its bioactive components and mechanisms of action could pave the way for its development as a safe and effective therapeutic alternative.