The role of granulocyte-macrophage colony‐stimulating factor in inducing autophagy in the spermatozoa of patients with asthenoteratozoospermia
These results revealed that GM-CSF has the potential to significantly induce autophagy in sperm and enhance sperm motility in patients with asthenoteratozoospermia, without adversely affecting sperm viability and DNA integrity. These findings suggest that modifying autophagy with physiological and safe components like GM-CSF may become a promising therapeutic strategy for treating male infertility in the near future.
Authors
- Mohammad Hossien Heidari (ORCID: https://orcid.org/0000-0002-0056-7555)
- Pourya Raee (ORCID: https://orcid.org/0000-0001-7262-9658)
- Marefat Ghaffari Novin (ORCID: https://orcid.org/0000-0003-4455-5211)
- Tahereh Gheliji (ORCID: https://orcid.org/0009-0000-9936-9382)
- Mahsa Kazemi (ORCID: https://orcid.org/0000-0001-9292-5315)
- Zahra Shams Mofarahe (ORCID: https://orcid.org/0000-0002-5134-1839)
- Bahareh Karimi (ORCID: https://orcid.org/0000-0002-3820-9462)
- Hamid Nazarian (ORCID: https://orcid.org/0000-0001-9920-5054)
- Latif Gachkar (ORCID: https://orcid.org/0000-0002-5314-5022)
Institutions
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.5653/cerm.2024.07479
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00