Comparative Evaluation of Efficacy of Coronally Advanced Flap With or Without A-PRF Membrane in The Treatment of Miller’s Class I / II Gingival Recession Defect- A Clinical Study

<p><strong>Abstract</strong></p> <p><strong>Introduction</strong></p> <p>Aesthetic concern is one of the main reasons behind the treatment of gingival recession defects. A lot of clinical evidence supports the applications of A-PRF in soft tissue healing, especially for the coverage of Miller’s class I and II gingival recession defects when combined with various root coverage procedures. A-PRF plays an important role as a biodegradable scaffold and favors the development of micro-vascularization. Coronally advanced flap is considered the gold standard approach for root coverage, and the addition of adjunctive use of A-PRF has a beneficial effect by releasing the growth factor and promoting the superior clinical outcome.</p> <p><strong>Aims and Objectives</strong></p> <p>1. To clinically evaluate the additional effectiveness of A-PRF membrane when used in combination with a Coronally advanced flap in the treatment of Miller’s Class I / II gingival recession defect.</p> <p>2. To assess and evaluate the clinical outcome in terms of clinical parameters such as recession depth, recession width, gingival thickness, and percentage of mean root coverage after root coverage procedure with or without the use of A-PRF.</p> <p><strong>Materials and Methods</strong></p> <p>A total of 20 patients with the age group of 30-50 years diagnosed with Miller’s Class I / II gingival recession defect were randomly selected & divided into two groups with 10 patients in each group: Group 1 (Test group): 10 patients treated with Coronally advanced flap surgery with a placement of Advanced Platelet-rich fibrin (A-PRF). Group 2 (Control Group): 10 patients treated with Coronally advanced flap surgery alone. Clinical parameters such as <a name="_Hlk162946317"></a>Pocket probing depth, clinical attachment level, recession depth, recession width, gingival thickness, and percentage of mean root coverage were recorded at baseline & after 1 month postoperatively.</p> <p><strong>Results</strong></p> <p>The mean root coverage (MRC) was 45% and 52%, for the Control group and Test group, respectively, after 1 month postoperatively. A statistically significant difference was demonstrated postoperatively between the two groups in terms of recession depth (RD), recession width (RW), Gingival Thickness (GT), percentage of mean root coverage, and Pocket Probing Depth (PPD) after 1 month. However, Clinical Attachment Level (CAL) was found to be non-significant.</p> <p><strong>Conclusion</strong></p> <p>The result obtained from the study showed that there is additional effectiveness of Advanced PRF when used with a combination of Coronally advanced flap in the treatment of Miller’s Class I / II gingival recession defect.</p> <p><strong>Keywords: </strong>Coronally advanced flap, Recession depth, Advanced platelet-rich fibrin, Periodontal Regeneration, growth factors</p>