Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation
Our investigation pinpointed a circular RNA, circCLASP2, which is upregulated in NPC and augments cytoskeletal functions via the DHX9-PCMT1 axis, contributing to the malignancy progression of NPC. This pathway holds promise as a potential therapeutic target for NPC. Furthermore, these molecules could also serve as biomarkers for adjunct diagnosis and prognosis assessment in NPC.
Authors
- Zhaojian Gong (ORCID: https://orcid.org/0000-0001-7501-3613)
- Hongke Qu
- Peng Miao (ORCID: https://orcid.org/0000-0003-3993-4778)
- Xiangchan Hou
- Ming Tan (ORCID: https://orcid.org/0000-0001-6565-699X)
- Yujuan Zhou (ORCID: https://orcid.org/0000-0002-5195-8724)
- Bo Xiang (ORCID: https://orcid.org/0000-0003-2641-5434)
- Zhaoyang Zeng (ORCID: https://orcid.org/0000-0002-0648-0565)
- Shan Zhang (ORCID: https://orcid.org/0009-0009-4050-4063)
- Dan Wang (ORCID: https://orcid.org/0000-0003-4085-4265)
- Wei Xiong (ORCID: https://orcid.org/0000-0003-1635-8173)
- Chunmei Fan (ORCID: https://orcid.org/0000-0003-2168-8054)
- Pan Wu (ORCID: https://orcid.org/0000-0003-3250-6770)
- Ming Zhou
- Guiyuan Li
- Qianjin Liao
- Junshang Ge
- Pan Chen (ORCID: https://orcid.org/0009-0001-7501-2802)
Institutions
- Central South University (CN)
- China Medical University (TW)
- Chinese PLA General Hospital (CN)
- Hunan Cancer Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12943-025-02272-3
- Citations
- 14
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 11.28
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province