Levodopa-induced motor complications associated with benserazide and carbidopa in Parkinson’s disease: a disproportionality analysis of the FAERS database
The findings indicate that the choice of DCI affects the risk profile of motor complications in PD. BSZ is associated with increased risks of dyskinesia and the on-off phenomenon, whereas CD is linked to a higher risk of wearing-off. Future research should explore the mechanisms underlying these differences to guide the selection of the most appropriate DCI for individual patients.
Authors
- Huaide Qiu (ORCID: https://orcid.org/0000-0001-8660-2755)
- Cheng Liu (ORCID: https://orcid.org/0000-0003-0508-0129)
- Zhixiang Wang (ORCID: https://orcid.org/0000-0002-6364-6891)
Institutions
- Jiangsu University (CN)
- Nanjing Normal University (CN)
- Yixing People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fphar.2025.1529932
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17