EFFECTIVENESS OF FERMENTED BLACK GLUTINOUS RICE SNACK BAR INTERVENTION ON ADULT IMMUNITY STATUS (INTERLEUKIN-6)

Background: Increased oxidative stress has a negative impact on several components of the cell membrane, namely damage to membrane lipids to form malonaldehyde. Free radicals can also cause the secretion of inflammatory mediators, namely IL-6 which acts as a pro-inflammatory cytokine. The content of Fermented Black Glutinous Rice Snack Bar is also expected to be able to reduce inflammation which is indicated by a decrease in IL-6 levels as an indicator of inflammation. Objective: This study aimed to know effectiveness of fermented black glutinous rice (FBGR) snack bars on adult immunity status (IL-6). Method: The study design was true experiment with a control group. There were 20 adult subjects (>20 years old) each group by purpose sampling method. Subjects were divided into two groups: the experimental group (FBGR snack bars administrated for 30 days) and the control group (no FBGR snack bars administration). IL-6 levels were collected pre and post intervention. Data analysis by double difference approach to compare immunity status (IL-6 levels alteration) of the two groups. Results: Wilcoxon Sign Rank statistic test showed that was significant difference IL-6 level pre and post intervention in control group (95% CI); significant difference IL-6 level reduced pre and post intervention in intervention group (95% CI). Independent T test showed that significant difference IL-6 level between intervention and control groups with p<0,001 (p<0,05) in 95% CI. Conclusion: This study concluded that FBGR snack bars intervention reduced IL-6 levels.