Ursodeoxycholic and chenodeoxycholic bile acids alleviate endotoxininduced acute lung injury in rats by modulating aquaporin expression and pathways associated with apoptosis and inflammation
This study demonstrates that UDCA and CDCA can mitigate endotoxin-induced lung injury in rats. These effects are achieved through modulation of AQP1 and AQP5 expression, reduction of oxidative stress, regulation of apoptotic pathways (BAX, caspase 3, BCL-2), and attenuation of pro-inflammatory activity of NF-κB. Although the results indicate a significant association between the expression of these proteins and histopathological changes, the potential influence of additional factors cannot be excluded. These findings suggest that UDCA and CDCA provide lung protection by acting through complex mechanisms involving inflammatory, oxidative, and apoptotic pathways.
Authors
- Aleksandar Petrović (ORCID: https://orcid.org/0000-0002-7105-7456)
- Radoslav Gajanin
- Mojca Matičič (ORCID: https://orcid.org/0000-0003-4261-0424)
- Uglješa Maličević (ORCID: https://orcid.org/0009-0004-7649-186X)
- Momir Mikov (ORCID: https://orcid.org/0000-0002-2804-0624)
- Ranko Škrbić (ORCID: https://orcid.org/0000-0002-6643-1781)
- Sergey Bolevich
- Alma Prtina
- Nebojša Mandić-Kovačević (ORCID: https://orcid.org/0000-0003-1790-0729)
- Milkica Grabež (ORCID: https://orcid.org/0000-0002-7770-6293)
- Tanja Cvjetković
- Tatjana Milivojac
- Milica Gajić Bojić (ORCID: https://orcid.org/0009-0006-8433-7808)
- Snežana Uletilović (ORCID: https://orcid.org/0000-0003-4219-5806)
- Miloš P. Stojiljković (ORCID: https://orcid.org/0000-0001-9431-0736)
- Ljiljana Amidžić
- Maja Barudžija (ORCID: https://orcid.org/0009-0007-9441-7569)
- Aleksandra Krivokuća (ORCID: https://orcid.org/0009-0004-9431-3848)
Institutions
- University of Nis (RS)
- University of Novi Sad (RS)
- University of Banja Luka (BA)
- Sechenov University (RU)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fphar.2025.1484292
- Citations
- 5
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 3.99