Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice
Suppression of the TDAR to SRBC immunization was the most sensitive immune endpoint being 33 times more sensitive than changes in liver weight, a commonly used outcome for risk assessment for PACs. Benzo(<i>a</i>)pyrene was the most potent PAC regarding suppression of humoral immunity whereas pyrene did not affect the immune responses tested. These studies lay the foundation for evaluating diverse PACs with a range of immunotoxicological potencies.
Authors
- Victor J. Johnson
- Suramya Waidyanatha (ORCID: https://orcid.org/0000-0001-9512-090X)
- Cynthia J. Willson
- Billie Stiffler
- Dori R. Germolec (ORCID: https://orcid.org/0000-0003-4072-1956)
- Gary R. Burleson
- Cynthia V. Rider (ORCID: https://orcid.org/0000-0002-4497-518X)
- Brian Burback
- Esra Mutlu (ORCID: https://orcid.org/0000-0001-6125-4045)
- Reshan A. Fernando (ORCID: https://orcid.org/0000-0002-9245-7790)
- James Blake (ORCID: https://orcid.org/0000-0001-9769-8529)
- Shawn Harris (ORCID: https://orcid.org/0000-0003-3169-9128)
- Veronica Godfrey
- Michael I. Luster
Institutions
- Battelle (US)
- RTI International (US)
- Triangle (US)
- Maryland Oncology Hematology (US)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Frontiers in Toxicology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/ftox.2025.1558639
- Primary Topic
- Immunotoxicology and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Environmental Health Sciences