Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls
While humoral responses to SARS-CoV-2 vaccines were weaker in patients with IEI, their cellular immunity was similar to controls. Boosters enhanced both humoral and cellular responses. After completion of the vaccination protocol, none of the patients with IEI were hospitalized with COVID-19. Robust T-cell responses may play a critical role in protecting patients with IEI from severe COVID-19 and mortality.
Authors
- Kathleen E. Sullivan (ORCID: https://orcid.org/0000-0003-4018-1646)
- Vitor Gabriel Lopes da Silva (ORCID: https://orcid.org/0000-0002-8802-8117)
- Carolina Sánchez Aranda (ORCID: https://orcid.org/0000-0002-2187-8192)
- G. Schmitz (ORCID: https://orcid.org/0000-0002-7069-1017)
- Maria Isabel de Moraes‐Pinto (ORCID: https://orcid.org/0000-0001-7345-5477)
- Júlia Barbate
- Maria Izabel de Haro Azinar
Institutions
- Children's Hospital of Philadelphia (US)
- Universidade de São Paulo (BR)
- University of Pennsylvania (US)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1538453
- Citations
- 3
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior