A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression
Our work strengthens the association between haploinsufficiency for <i>CRIM1</i> and eye defects and characterizes a stable model of <i>crim1</i> loss of function for future research.
Authors
- Sergio E. Baranzini (ORCID: https://orcid.org/0000-0003-0067-194X)
- Manoj K. Pandey (ORCID: https://orcid.org/0000-0002-0495-830X)
- Anne Slavotinek (ORCID: https://orcid.org/0000-0001-7053-2449)
- Stephanie Htun
- Tien Le (ORCID: https://orcid.org/0000-0003-3566-1784)
- Albert Frank Magnusen
- Bin Guan (ORCID: https://orcid.org/0000-0002-5210-6216)
- Yihui Sun (ORCID: https://orcid.org/0009-0000-5507-9105)
- Ehsan Ullah (ORCID: https://orcid.org/0000-0002-9881-6731)
- Robert B. Hufnagel (ORCID: https://orcid.org/0000-0003-3015-3545)
- Julie Lauzon
- Brian P. Brooks
- Chung Lee
- Shannon Beres
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- National Institutes of Health (US)
- University of Calgary (CA)
- University of California, San Francisco (US)
- Alberta Children's Hospital (CA)
- National Eye Institute (US)
- University of Cincinnati Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3389/fcell.2025.1522094
- Citations
- 1
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Institutes of Health
- National Eye Institute