Zebrafish as a model for investigating <i>Klebsiella pneumoniae</i> -driven lung injury and therapeutic targets
<b>Conclusions:</b> This zebrafish model effectively mimics K. pneumoniae-induced lung injury, offering valuable insights into the molecular mechanisms of tissue damage and immune dysregulation. Targeting the TGF-β signaling pathway holds therapeutic potential for reducing inflammation and promoting tissue repair, providing a foundation for the development of new treatment strategies for lung infections.
Authors
- Xiaohong Rui (ORCID: https://orcid.org/0000-0002-4078-3703)
- Lei Lü (ORCID: https://orcid.org/0000-0002-8192-1471)
- Fan Tu (ORCID: https://orcid.org/0000-0002-5673-5300)
- Zhongbo Shang
- Jian Ye (ORCID: https://orcid.org/0000-0002-7741-4354)
- Jun Liu (ORCID: https://orcid.org/0000-0002-5815-2483)
- Ming Ren (ORCID: https://orcid.org/0000-0002-9234-0672)
Institutions
- Jiangnan University (CN)
- Wuqing District People's Hospital (CN)
- Jiangxi Provincial Children's Hospital (CN)
Publication Details
- Journal
- Experimental Lung Research
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1080/01902148.2025.2472328
- Citations
- 4
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.61