Dysregulated ATX-LPA and YAP/TAZ signaling in dystrophic Sgcd−/− mice with early fibrosis and inflammation
The ATX-LPA axis and the YAP/TAZ signaling pathway, which are involved in inflammation and fibrosis, are dysregulated in skeletal muscle from an early age in Sgcd<sup>-/-</sup> mice. These changes are concomitant with a fibrotic and inflammatory response in these mice. Unraveling the role of the LPA axis and YAP/TAZ in sarcoglycanopathy holds great promise for improving our understanding of disease pathogenesis and identifying novel therapeutic targets for this currently incurable group of muscle disorders.
Authors
- Meilyn Cruz-Soca (ORCID: https://orcid.org/0000-0002-3837-8741)
- Elisabeth R. Barton (ORCID: https://orcid.org/0000-0002-7401-4398)
- Juan Carlos Casar (ORCID: https://orcid.org/0000-0001-6494-5730)
- Jennifer Faundez-Contreras
- Cristian Gutiérrez‐Rojas
- Adriana Córdova-Casanova (ORCID: https://orcid.org/0000-0002-1526-264X)
- Enrique Brandan (ORCID: https://orcid.org/0000-0002-6820-5059)
- Alexia Bock-Pereda (ORCID: https://orcid.org/0000-0001-9024-9296)
- Felipe S. Gallardo
Institutions
- Pontificia Universidad Católica de Valparaíso (CL)
- Pontificia Universidad Católica de Chile (CL)
- San Sebastián University (CL)
- University of Florida (US)
- Fundación Ciencia and Vida (CL)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s13395-025-00375-5
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30