New 14,15-dinor- <i>neo</i> -clerodane and <i>neo</i> -clerodane diterpenoids from <i>Ajuga macrosperma</i> Wall. ex benth

One new diterpenoid possessing a rare 14,15-dinor-<i>neo</i>-clerodane framework, ajugamacrin H (<b>1</b>), and one new <i>neo</i>-clerodane diterpenoid, ajugamacrin I (<b>2</b>), along with seven known analogues (<b>3</b>-<b>9</b>), were obtained from <i>Ajuga macrosperma</i> Wall. ex Benth.. Structures of compounds <b>1</b> and <b>2</b> were elucidated primarily based on NMR and MS methods, and their absolute configurations were identified via ECD calculations. <b>3</b>, <b>7</b>, and <b>8</b> exhibited inhibitory activities on NO production in LPS-stimulated RAW 264.7 cells at 50 <i>μ</i>M. Moreover, compounds <b>1</b>-<b>9</b> were evaluated for their antibacterial effects against four strains of bacteria.