Association between <i>TMEM132D</i> gene polymorphisms and depressive symptoms in Qingdao Chinese elderly

The relationship between <i>TMEM132D</i> and depressive symptoms in community populations has not been investigated. Therefore, we explored the association between <i>TMEM132D</i> gene polymorphism and depressive symptoms based on data from a community sample of older adults in Qingdao. A total of 863 older adults were included in this study to examine the relationship between 12 SNPs and depressive symptoms. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Logistic regression analysis was used to analyze the relationship between SNPs and depressive symptoms based on five genetic models. Finally, linkage disequilibrium analysis was performed, and haplotype domains were constructed. We discovered a statistically significant difference between groups with and without depressive symptoms in the genotype and allele frequencies of rs2292723. In addition, multivariate logistic regression showed that rs2292723 and rs2170820 were positively associated with depressive symptoms, and rs61944776 was negatively associated with depressive symptoms. Finally, we found that the haplotype "CTC" of rs2292723, rs492759, and rs61944776 was significantly associated with depressive symptoms by haplotype analysis. Our study suggested that <i>TMEM132D</i> was associated with depressive symptoms, which supplemented the role of the <i>TMEM132D</i> gene in psychiatric disorders.