Recent Developments in the Synthesis of Benzothiazoles and their Anti-cancer Mechanistic Discoveries
Benzothiazole derivatives have garnered considerable attention owing to their versatile chemical scaffold and remarkable biological activities. The article provides an in-depth analysis of the diverse structural modifications and strategies employed to enhance the anticancer potential of these compounds from the period of 2020 to 2024. It discusses the role of structure-activity relationships (SAR) and computational approaches in optimizing benzothiazole derivatives for selective and effective cancer treatment.
Authors
- Rasha A. Azzam (ORCID: https://orcid.org/0000-0002-6807-2110)
- Wafaa A. Zaghary (ORCID: https://orcid.org/0000-0002-9037-9696)
- Galal H. Elgemeie (ORCID: https://orcid.org/0000-0003-3268-5975)
- Tamer M. Sakr (ORCID: https://orcid.org/0000-0001-9162-5687)
- Safa A. Aljuhr
Institutions
- Egyptian Atomic Energy Authority (EG)
- Helwan University (EG)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-03-06
- DOI
- https://doi.org/10.2174/0113816128355783250212043621
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.94