Changes in triglyceride-rich lipoprotein particle profiles in response to one-week on a low fat or Mediterranean diet by TCF7L2 rs7903146 genotype: a randomized crossover dietary intervention trial
Our findings suggest that rs7903146 TT carriers benefit more from a MetD than a LF diet in terms of their triglyceride-rich lipoprotein profile, which may reduce their risk of CVD. These results support the notion that genotype is a factor in determining the extent to which the MetD affects cardiovascular health.
Authors
- Laurence D. Parnell (ORCID: https://orcid.org/0000-0001-9718-1335)
- José M. Ordovás (ORCID: https://orcid.org/0000-0002-7581-5680)
- Julie E Gervis (ORCID: https://orcid.org/0000-0003-0125-9930)
- Chao‐Qiang Lai (ORCID: https://orcid.org/0000-0003-1107-8375)
- Alice H. Lichtenstein
Institutions
- Madrid Institute for Advanced Studies (ES)
- Tufts University (US)
- Instituto de Salud Carlos III (ES)
- IMDEA Food (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Genes & Nutrition
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12263-025-00763-y
- Citations
- 2
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Allen Foundation
- Agricultural Research Service