Supramolecular Partners: Precision On/Off Neuromuscular Blockage for Prolonged Surgeries
The development of a long-acting neuromuscular blocking agent and its on-demand reversal is highly desired for prolonged surgeries. This viewpoint discussed the discovery of supramolecular partners, an imidazolium-based macrocycle (YW70271) and acyclic cucurbit[n]uril (WY22051), for ultralong neuromuscular blockade and rapid reversal.
Authors
- Ruibing Wang (ORCID: https://orcid.org/0000-0001-9489-4241)
- Hang Yin (ORCID: https://orcid.org/0000-0002-2898-844X)
- Ziyi Wang (ORCID: https://orcid.org/0000-0002-4144-8034)
Institutions
- University of Macau (MO)
- Quality Research (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c00557
- Citations
- 1
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China