FLRT3 Overexpression Attenuates Ischemia–Reperfusion Induced Vascular Hyperpermeability and Lung Injury Through RND3
Our findings reveal FLRT3, a critical regulator of endothelial barrier function during IRI through the RND3-RhoA pathway, is a potential therapeutic target for pulmonary IRI.
Authors
- Yingchuan Li (ORCID: https://orcid.org/0000-0002-5522-4402)
- Yong Zhong (ORCID: https://orcid.org/0000-0003-1446-3148)
- Yongmei Cao (ORCID: https://orcid.org/0000-0002-8261-3008)
- Wei-Feng Huang (ORCID: https://orcid.org/0000-0002-9755-7299)
- Shiyang Sheng (ORCID: https://orcid.org/0000-0001-8484-2050)
- Jin Cui (ORCID: https://orcid.org/0000-0001-5530-4843)
- Yongchao Liu (ORCID: https://orcid.org/0000-0002-8092-9906)
- Ping Feng (ORCID: https://orcid.org/0000-0001-9163-2238)
- Qin Tan
- Jiawei Shang (ORCID: https://orcid.org/0000-0002-3944-5619)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Tenth People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Lung
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1007/s00408-025-00791-w
- Citations
- 1
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Natural Science Foundation of China