Transcallosal white matter and cortical gray matter variations in autistic adults aged 30–73 years
Our findings revealed increased free water load in frontal white matter in autistic adults and identified distinct age-associated microstructural variations between the two groups. These findings highlight more heterogeneous brain aging profiles in autistic adults. Our study also demonstrated the importance of quantifying free water in dMRI studies of ASD.
Authors
- David E. Vaillancourt (ORCID: https://orcid.org/0000-0002-5663-6476)
- Bradley J. Wilkes (ORCID: https://orcid.org/0000-0003-0477-3505)
- Zheng Wang (ORCID: https://orcid.org/0000-0003-2265-0891)
- Jingying Wang (ORCID: https://orcid.org/0000-0002-9766-2769)
- Stephen A. Coombes (ORCID: https://orcid.org/0000-0001-8616-5364)
- Desirae J. Shirley
- Regilda A. Romero
- Danielle Christensen
- Young Seon Shin
- Ann-Marie Orlando
Institutions
- University of Florida Health (US)
- University of Florida (US)
- Center for Autism and Related Disorders (US)
Publication Details
- Journal
- Molecular Autism
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s13229-025-00652-6
- Citations
- 7
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 10.02
Funders
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke