PROBIOTIC EFFECTS ON OXIDATIVE STRESS PATHWAYS IN DIABETES

Diabetes is a complex metabolic disorder characterized by chronic hyperglycaemia and associated with significant oxidative stress, which contributes to the progressive damage of vital tissues.This study evaluates the potential benefits of probiotics in managing oxidative stress by administering them to both untreated diabetic groups and diabetic groups receiving standard antidiabetic therapy.Oxidative stress markers were assessed in the brain to explore the gut-brain axis and its connection to microbiota enrichment, while liver analysis provided insights into peripheral impact.The results revealed significant strainspecific variations in key parameters, highlighting the potential of probiotics to regulate oxidative stress and complement antidiabetic therapy. RezumatDiabetul este o tulburare metabolic complex, caracterizat prin hiperglicemie cronic i asociat cu un stres oxidativ semnificativ, care contribuie la deteriorarea progresiv a esuturilor vitale.Acest studiu evalueaz beneficiile poteniale ale probioticelor n gestionarea stresului oxidativ prin administrarea acestora att la grupuri diabetice netratate, ct i la grupuri diabetice tratate cu terapie antidiabetic standard.Markerii stresului oxidativ au fost analizai n creier pentru a explora axa intestin-creier i conexiunea acesteia cu mbogirea microbiotei, n timp ce analiza ficatului a oferit informaii despre impactul periferic.Rezultatele au evideniat variaii semnificative, specifice tulpinilor de probiotice utilizate, subliniind potenialul acestora de a regla stresul oxidativ i de a completa terapia antidiabetic.