LncRNA MIR181A1HG Deficiency Attenuates Vascular Inflammation and Atherosclerosis
These findings identify MIR181A1HG as a central driver of vascular inflammation in atherosclerosis by its ability to decoy Foxp1 away from target gene promoters and activate NLRP3 inflammasome in the vascular endothelium. Our study suggests MIR181A1HG as a future therapeutic target for vascular inflammatory disease states.
Authors
- Weifeng Li (ORCID: https://orcid.org/0000-0002-0244-2908)
- Rulin Zhuang (ORCID: https://orcid.org/0000-0003-4557-4289)
- Mark W. Feinberg (ORCID: https://orcid.org/0000-0001-9523-3859)
- Shen Gu (ORCID: https://orcid.org/0000-0001-6888-770X)
- Yulong Ge (ORCID: https://orcid.org/0000-0002-3541-7354)
- Qiuling Wang (ORCID: https://orcid.org/0000-0002-1066-5909)
- Huaner Ni (ORCID: https://orcid.org/0000-0002-9651-3411)
- Ying Zhuge (ORCID: https://orcid.org/0000-0003-2952-4302)
- Fang Wang (ORCID: https://orcid.org/0000-0001-8367-8973)
- Xiang Wang (ORCID: https://orcid.org/0000-0003-0992-8553)
- Hangwei Chen (ORCID: https://orcid.org/0000-0002-1057-3772)
- Xiaoqiang Liu (ORCID: https://orcid.org/0000-0003-0108-5918)
- Junyi Liu (ORCID: https://orcid.org/0000-0001-5667-7983)
Institutions
- Brigham and Women's Hospital (US)
- Shanghai Jiao Tong University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1161/circresaha.124.325196
- Citations
- 23
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 21.53