Identification of disease-specific pathways and modifiers in phospholamban R14del cardiomyopathy: rationale, design and baseline characteristics of DECIPHER-PLN cohort
DECIPHER-PLN comprises R14<sup>∆/+</sup> carriers across the disease and non-disease spectrum and can be used to identify disease-specific biological pathways and modifiers that play a role in R14<sup>∆/+</sup> cardiomyopathy. Using a multi-omics approach and in vitro disease modelling, we aim to identify novel biomarkers and improve our understanding of R14<sup>∆/+</sup> pathophysiology. Material is available upon request.
Authors
- Nils Bömer (ORCID: https://orcid.org/0000-0001-5926-6960)
- Remco de Brouwer (ORCID: https://orcid.org/0000-0002-5705-2034)
- Frederik E. Deiman (ORCID: https://orcid.org/0000-0001-9793-4683)
- Lukas Baumhove (ORCID: https://orcid.org/0000-0002-5860-7943)
- Niels Grote Beverborg (ORCID: https://orcid.org/0000-0003-4629-9960)
- Peter van der Meer (ORCID: https://orcid.org/0000-0002-9705-4413)
Institutions
- University Medical Center Groningen (NL)
Publication Details
- Journal
- Netherlands Heart Journal
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1007/s12471-025-01941-8
- Citations
- 2
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78