Long-term exposure of indoxyl sulfate induces mesothelial-to-mesenchymal transition of peritoneal mesothelial cells via β-catenin-involved signaling pathway
Indoxyl sulfate induces MMT in human peritoneal mesothelial cells, and these changes can be reversed by the specific β-catenin inhibitor ICG-001. This suggests that IS may be considered as another inducer of MMT during PD through the β-catenin signaling pathway.
Authors
- Qiang Wang (ORCID: https://orcid.org/0000-0002-8462-2063)
- Guoqing Yu
- Liu Run-mei
- Xiaoxue Weng
- Wen Wen (ORCID: https://orcid.org/0009-0003-1873-7262)
Institutions
- Fujian Medical University (CN)
Publication Details
- Journal
- Advances in Clinical and Experimental Medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.17219/acem/195869
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00