Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer
Targeting the CTHRC1+ CAF-WNT5A-MSLN signaling axis presents a promising therapeutic strategy for advanced CRC patients. Our study provides new insights into the role of CAFs in CRC progression and offers potential avenues for developing targeted therapies to disrupt this pathway.
Authors
- Hengyang Shen
- Changzhi Huang
- Zan Fu (ORCID: https://orcid.org/0000-0002-3397-0770)
- Ying Tong
- Lei Xu
- Yunfei Lu (ORCID: https://orcid.org/0000-0002-9292-2517)
- Yang Chen (ORCID: https://orcid.org/0000-0003-2741-8274)
- Zhenling Wang (ORCID: https://orcid.org/0000-0002-6834-8607)
- Yu Shao
- Hongqiang Zhang (ORCID: https://orcid.org/0009-0006-5787-6689)
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12967-025-06236-5
- Citations
- 20
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 16.12
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China