THE RELATIONSHIP BETWEEN INSULIN RESISTANCE, BODY COMPOSITION, AND SEVERE ACNE: A CROSS-SECTIONAL ANALYSIS

Recent evidence suggests a potential link between acne severity and insulin resistance (IR).This cross-sectional study of 152 acne patients explored this association, considering factors such as fat-free mass (FFM), fat mass (FM), visceral fat (VF) and glutathione peroxidase (GPx) activity.Patients were categorized into two groups: a control group (CG, N = 80) with acne but no IR and an IR group (IRS-G, N = 72) with both acne and IR.The study assessed the likelihood of severe acne in the presence of IR and evaluated its relationship with body composition indices.Severe acne was significantly more common in the IRS-G (p < 0.05), which also displayed higher BMI, FM and VF (p < 0.05) and lower GPx activity (p < 0.001) compared to the CG.Elevated HOMA-IR values correlated positively with BMI, FM, VF and acne severity (p < 0.001) and negatively with GPx activity (p < 0.001).These findings highlight that IR, alongside higher BMI, FM, VF, and reduced GPx activity, strongly predicts severe acne.IR and associated metabolic parameters significantly influence acne severity.Larger, multicentre prospective studies are warranted to confirm these findings and elucidate the mechanisms underlying this relationship. RezumatDovezi recente sugereaz o posibil legtur ntre severitatea acneei i rezistena la insulin (RI).Acest studiu transversal, realizat pe 152 de pacieni cu acnee, a investigat aceast asociere, analiznd factori precum masa fr grsime (FFM), masa gras (FM), grsimea visceral (VF) i activitatea glutation-peroxidazei (GPx).Pacienii au fost mprii n dou grupuri: un grup de control (CG, N = 80) cu acnee, dar fr RI, i un grup cu RI (IRS-G, N = 72), avnd att acnee, ct i RI.Studiul a evaluat probabilitatea de apariie a unei forme severe de acnee n prezena RI i a analizat relaia acesteia cu indicii de compoziie corporal.Acneea sever a fost semnificativ mai frecvent n grupul IRS-G (p < 0,05), care a prezentat valori mai ridicate ale IMC, FM i VF (p < 0,05) i activitate GPx mai sczut (p < 0,001) comparativ cu grupul de control.Valorile crescute ale HOMA-IR s-au corelat pozitiv cu IMC, FM, VF i severitatea acneei (p < 0,001) i negativ cu activitatea GPx (p < 0,001).Aceste rezultate indic faptul c RI, asociat cu IMC, FM, VF mai ridicate i activitate GPx sczut, este un predictor puternic al acneei severe.RI i parametrii metabolici asociai influeneaz semnificativ severitatea acneei.Sunt necesare studii prospective mai mari, multicentrice, pentru confirmarea acestor concluzii i clarificarea mecanismelor implicate.