LOW MOLECULAR WEIGHT HEPARIN IN THE PROTECTION OF PARATHYROID FUNCTION AFTER THYROID SURGERY

Permanent hypoparathyroidism is a severe complication of thyroid surgery, affecting postoperative quality of life.This study investigated the protective effects of low molecular weight heparin (LMWH) on parathyroid function in 92 patients undergoing total thyroidectomy (June 2019-June 2023).Patients were divided into a control group (CG) receiving standard care and an experimental group (EG) receiving prophylactic calcium LMWH.LMWH (4000 AXaIU enoxaparin) was administered subcutaneously before and after surgery.Coagulation markers, parathyroid indicators and inflammatory markers were assessed pre-and post-operatively.EG showed improved coagulation function and reduced postoperative inflammation (lower IL-6 and CRP levels) compared to CG.Although both groups experienced transient reductions in parathyroid function, recovery was comparable by day 180, with no permanent hypoparathyroidism observed.LMWH improved postoperative outcomes by mitigating hypercoagulability, reducing inflammation and supporting parathyroid function, suggesting its potential benefit in thyroid surgery. RezumatHipoparatiroidismul permanent este o complicaie sever a chirurgiei tiroidiene, afectnd calitatea vieii postoperatorii.Acest studiu a investigat efectele heparinei cu greutate molecular mic (LMWH) asupra funciei paratiroidiene la 92 de pacieni supui tiroidectomiei totale (n perioada iunie 2019-iunie 2023).Pacienii au fost mprii ntr-un grup de control (CG), care a primit terapie standard i un grup experimental (EG) care a primit LMWH i calciu profilactic.LMWH (4000 AXaIU enoxaparina) a fost administrat subcutanat nainte i dup operaie.Markerii de coagulare, indicatorii paratiroidieni i markerii inflamatori au fost evaluai nainte i dup operaie.EG a prezentat o activitate de coagulare mbuntit i inflamaie postoperatorie redus (niveluri mai sczute de IL-6 i CRP) comparativ cu CG.Dei ambele grupuri au prezentat reduceri tranzitorii ale funciei paratiroidiene, recuperarea a fost comparabil pn n ziua 180, fr a se observa hipoparatiroidism permanent.LMWH a mbuntit rezultatele postoperatorii prin atenuarea hipercoagulabilitii, reducerea inflamaiei i susinerea funciei paratiroidiene, sugernd potenialele avantaje n chirurgia tiroidian.