THE ROLE OF 3D PRINTING IN THE DEVELOPMENT OF DOSAGE FORMS WITH TAILORED DRUG RELEASE

In recent years, there has been growing interest in the application of 3D printing technology in the production of drug delivery systems.The particular advantages of using 3D printing lie in the production of drug delivery systems with dose, appearance (size, shape, colour, etc.) and drug release pattern tailored to the characteristics of each patient.This enables more efficient therapy, improved patient compliance, reduced costs, and fewer side effects.Due to simple fabrication of very complex architectures, 3D printing offers far greater opportunities to achieve the desired drug release patterns compared to conventional methods of manufacturing dosage forms.Numerous studies describe the successful application of 3D printing in the development of drug delivery systems with different release patterns, from simple immediate and prolonged release to more complex multiphasic release systems and trigger-induced drug release systems.Tailored drug release from 3D-printed drugs can be achieved in two ways: by fabrication of dosage forms of appropriate design or fabrication of device that controls the release of drugs from inserted dosage form prepared by conventional techniques.This article provides a brief overview of different 3D printing approaches used in the development of dosage forms with tailored drug release. Rezumatn ultimii ani, a existat un interes tot mai mare pentru aplicarea tehnologiei de imprimare 3D n producia medicamentelor cu eliberare controlat.Avantajele utilizrii imprimrii 3D constau n realizarea de sisteme de eliberare a medicamentelor cu doz, aspect (dimensiune, form, culoare, etc.) i profil de eliberare adaptate caracteristicilor fiecrui pacient.Acest lucru permite o terapie mai eficient, o mai bun aderen a pacientului, costuri reduse i mai puine efecte secundare.Datorit posibilitii de fabricare simpl a unor structuri foarte complexe, imprimarea 3D ofer oportuniti mult mai mari de a obine profilele dorite de eliberare a medicamentelor comparativ cu metodele convenionale de producie a formelor farmaceutice.Numeroase studii descriu aplicarea cu succes a imprimrii 3D n dezvoltarea sistemelor de eliberare a medicamentelor cu profile diferite de eliberare, de la eliberare imediat i prelungit pn la sisteme mai complexe cu eliberare multifazic i eliberare indus de factori declanatori.Eliberarea personalizat a medicamentelor din formele obinute prin imprimare 3D poate fi realizat n dou moduri: prin fabricarea formelor farmaceutice cu un design adecvat sau prin fabricarea unui dispozitiv care controleaz eliberarea medicamentelor din forma de dozaj inserat, pregtit prin tehnici convenionale.Acest articol sintetizeaz diferitele abordri de imprimare 3D utilizate n dezvoltarea formelor farmaceutice cu eliberare personalizat.