Modular Combinatorial DNA Assembly of Group B Streptococcus Capsular Polysaccharide Biosynthesis Pathways to Expediate the Production of Novel Glycoconjugate Vaccines
In conclusion, we report the first demonstration of heterologous GBS CPS IV and V biosynthesis in <i>E. coli</i>, a key milestone towards the development of low-cost recombinant multivalent GBS glycoconjugate vaccines.
Authors
- Ian J. Passmore (ORCID: https://orcid.org/0000-0002-4418-6957)
- Brendan W. Wren (ORCID: https://orcid.org/0000-0002-6140-9489)
- Elizabeth Atkins (ORCID: https://orcid.org/0000-0002-1783-6889)
- Alexandra Faulds‐Pain
- John Heap (ORCID: https://orcid.org/0000-0001-9991-5160)
- Mark A. Harrison (ORCID: https://orcid.org/0000-0001-7264-9990)
Institutions
- University of Nottingham (GB)
- London School of Hygiene & Tropical Medicine (GB)
Publication Details
- Journal
- Vaccines
- Published
- 2025-03-06
- DOI
- https://doi.org/10.3390/vaccines13030279
- Citations
- 1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Wellcome
- Medical Research Council
- Biotechnology and Biological Sciences Research Council