Epigenome-wide analysis reveals potential biomarkers for radiation-induced toxicity risk in prostate cancer
Epigenetic biomarkers show potential for predicting severe long-term adverse effects of RT in prostate cancer patients. The identified methylation patterns provide valuable insights into toxicity mechanisms and may aid personalized treatment strategies. However, validation in independent cohorts is essential to confirm their predictive value and clinical applicability.
Authors
- Ana M. Carballo (ORCID: https://orcid.org/0000-0001-8470-4934)
- Ana Vega (ORCID: https://orcid.org/0000-0002-7416-5137)
- Paula Peleteiro (ORCID: https://orcid.org/0000-0002-8900-2541)
- Ramón Lobato-Busto (ORCID: https://orcid.org/0000-0001-8888-8910)
- Begoña Taboada‐Valladares (ORCID: https://orcid.org/0000-0003-1635-7955)
- Antonio Gómez‐Caamaño (ORCID: https://orcid.org/0000-0002-9773-4590)
- Miguel E. Aguado‐Barrera (ORCID: https://orcid.org/0000-0002-7822-6726)
- Patricia Calvo (ORCID: https://orcid.org/0000-0002-0198-8992)
- Olivia Fuentes-Ríos (ORCID: https://orcid.org/0000-0002-9089-6765)
- Carlos Lopez-Pleguezuelos (ORCID: https://orcid.org/0009-0000-8898-5710)
- Carla Coedo-Costa
- Javier Galego-Carro
Institutions
- Universidade de Santiago de Compostela (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Fundación Pública Galega de Medicina Xenómica (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s13148-025-01846-8
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundación Científica Asociación Española Contra el Cáncer