Comparative analysis of various hair peptide serums in managing telogen effluvium in females: Efficacy, safety, and patient satisfaction

Objectives The aim of this study was to evaluate the efficacy and safety of three hair serums containing different active ingredients Capilia longa and combinations, cytokines and peptides, and redensyl and aminexil in managing Telogen effluvium (TE). Material and Methods An open-label, triple-arm, single-center, and comparative study was conducted over 90 days, enrolling 45 adult females with TE. Subjects were randomized into three groups ( n = 15 each): Group 1 (plant stem cell-based serum), Group 2 (cytokine-based serum), and Group 3 (redensyl and aminexil-based serum). Hair shedding was assessed through a hair wash test, trichoscopy, and clinical evaluations, and safety was monitored throughout. Results All groups demonstrated hair shedding reduction, with Group 2 showing the most significant decrease (54.6% reduction in hair fall) compared to Group 1 (23.9%) and Group 3 (26.3%). Trichoscopy analysis revealed improvements in hair count, density, and anagen percentage across groups, with Group 2 showing the highest increases in anagen percentage (+6.16%) and hair density (64.74%). No adverse events were reported, indicating good tolerability. Conclusion All three hair serum formulations were effective in reducing shedding and promoting hair regrowth in TE. Among them, cytokine-based hair serum (Group 2) showed the greatest efficacy followed by the other formulations. Hair serums can serve as a valuable adjunctive treatment for TE.