The Use and Side Effect Profile of Valproate and Lamotrigine in Child and Adolescent Psychiatry

Aim: Depressive and bipolar disorder are increasingly recognized psychiatric disorders in children and adolescents. Pharmacotherapy plays a significant role in managing symptoms in these patients. The research aims to investigate the effects and treatment side effect profiles of drugs such as lamotrigine and valproate commonly used in youth. Materials and Methods: A total of 80 patients who had received treatment at a tertiary care psychiatric hospital were included in the study. These patients were diagnosed with major depressive disorders bipolar disorder, conduct disorder, early-onset schizophrenia, and autism spectrum disorder. Demographic characteristics, diagnoses, and treatment durations of the patients were recorded. Treatment response was evaluated using symptom severity scales. Side effects after the start of medication were recorded. Results: Lamotrigine and valproate treatment have been found to be effective in treating mood disorders and irritability symptoms in children and adolescents. Mild side effects such as sedation (n=29) and easy fatigue (n=33) were more frequent in patients receiving lamotrigine and valproate treatment. Rash (n=2) and polycystic ovary syndrome (n=1) were seen much less frequently. Tremor and polycystic ovary syndrome were more frequent in patients receiving valproate treatment, while itching and rash were reported in those receiving lamotrigine. Conclusion: The findings of the investigation suggest that lamotrigine and valproate are easily tolerated in the treatment of mood disorders and irritability symptoms during child and adolescence. The use of valproate and lamotrigine treatments should be considered for children and adolescents where appropriate. Side effects that could significantly impact treatment adherence are rarely observed.