Merging metabolomics and genomics provides a catalog of genetic factors that influence molecular phenotypes in pigs linking relevant metabolic pathways
This study has provided the first catalog of genetic factors affecting molecular phenotypes that describe the pig blood metabolome, with links to important metabolic pathways, opening novel avenues to merge genetics and nutrition in this livestock species. The obtained results are relevant for basic and applied biology and to evaluate the pig as a biomedical model. Genetically influenced metabolites can be further exploited in nutrigenetic approaches in pigs. The described molecular phenotypes can be useful to dissect complex traits and design novel feeding, breeding and selection programs in pigs.
Authors
- Gianluca Mazzoni (ORCID: https://orcid.org/0000-0003-2397-1064)
- Flaminia Fanelli (ORCID: https://orcid.org/0000-0003-2601-2694)
- Paolo Trevisi (ORCID: https://orcid.org/0000-0001-7019-6828)
- Paolo Bosi (ORCID: https://orcid.org/0000-0002-0755-8002)
- Valeria Taurisano (ORCID: https://orcid.org/0000-0001-5349-1606)
- Anisa Ribani (ORCID: https://orcid.org/0000-0001-6778-1938)
- Pier Luigi Martelli (ORCID: https://orcid.org/0000-0002-0274-5669)
- Rita Casadio (ORCID: https://orcid.org/0000-0002-7462-7039)
- Samuele Bovo (ORCID: https://orcid.org/0000-0002-5712-8211)
- Diana Luise (ORCID: https://orcid.org/0000-0001-7864-7822)
- Luca Fontanesi (ORCID: https://orcid.org/0000-0001-7050-3760)
- Giuliano Galimberti (ORCID: https://orcid.org/0000-0002-9161-9671)
- Giuseppina Schiavo (ORCID: https://orcid.org/0000-0002-3497-1337)
- Uberto Pagotto (ORCID: https://orcid.org/0000-0003-4182-3110)
- Francesca Bertolini (ORCID: https://orcid.org/0000-0003-4390-0394)
- Paolo Zambonelli (ORCID: https://orcid.org/0000-0002-2532-5528)
- Matteo Bolner (ORCID: https://orcid.org/0000-0002-4985-0191)
- Stefania Dall’Olio (ORCID: https://orcid.org/0000-0003-1384-3771)
- Maurizio Gallo (ORCID: https://orcid.org/0000-0001-6281-426X)
Institutions
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- ANT Foundation Italy Onlus (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Genetics Selection Evolution
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1186/s12711-025-00960-8
- Citations
- 6
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Ministero delle Politiche Agricole Alimentari e Forestali
- Università di Bologna
- Ministero dell'Università e della Ricerca
- HORIZON EUROPE Framework Programme
- Horizon 2020