Enantioselective Desymmetrization of Phosphinic Acids via Cu-Catalyzed O-Arylation
Enantioselective desymmetrization of phosphinic acid with two completely different carbon substituents on the P atom is an efficient way to obtain chiral P(V) compounds with high structural diversity. Herein, we reported a Cu-catalyzed asymmetric arylation of phosphinic acid, which turns the P-center to be a versatile electrophile for obtaining a series of chiral P(V) compounds, including phosphinates, phosphinamides, and tertiary phosphine oxides, in good yields and high enantioselectivities.
Authors
- Dongmei Fang (ORCID: https://orcid.org/0000-0002-0418-1238)
- Zhuo Tang (ORCID: https://orcid.org/0000-0002-5845-3569)
- Xin Cui (ORCID: https://orcid.org/0000-0001-8371-353X)
- Ming Yan (ORCID: https://orcid.org/0000-0001-9888-0744)
- Jiawei Zou (ORCID: https://orcid.org/0009-0004-2589-4765)
- Guangxun Li (ORCID: https://orcid.org/0000-0001-6782-2066)
- Shiqi Zhang (ORCID: https://orcid.org/0000-0002-2120-1544)
Institutions
- Leshan Normal University (CN)
- Chengdu Institute of Biology (CN)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1021/acscatal.5c00439
- Citations
- 10
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 5.37
Funders
- Sichuan Province Science and Technology Support Program
- Chengdu Institute of Biology