Photocatalytic α-C(sp<sup>3</sup>)–H Arylation/Heteroarylation of Amines Enabled by Pyrylium Salt
A general photocatalytic α-C(sp<sup>3</sup>)-H arylation/heteroarylation of amines has been developed. In the presence of the newly designed DPA-TPT, the reaction can operate under mild conditions and produce a diverse array of tertiary benzylic amines in good yields. Additionally, the late-stage arylation of tetracaine demonstrated the practical application of this protocol, highlighting its versatility and efficiency in functionalizing complex molecules.
Authors
- Wentao Xu (ORCID: https://orcid.org/0000-0003-3490-2769)
- Hu Cai (ORCID: https://orcid.org/0000-0003-2372-3319)
- Yuhua Zhong
- Jiemin Ma
Institutions
- Nanchang University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1021/acs.joc.5c00090
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Nanchang University